NEDD9 Antibody

• Background:

  Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B-and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

• NCBI Gene ID:

  4739

• Swiss Prot:

  Q14511

• Accession Number:

  Q14511

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the Central region of human NEDD9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NEDD9

• NCBI Official Name:

  Enhancer of filamentation 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)

• Background Reference 02:

  Lucas, J.T. Jr., et al. Oncogene 29 (31) :4449-4459 (2010)

• Background Reference 03:

  Tedde, A., et al. Neurosci. Lett. 477 (3) :121-123 (2010)

• Background Reference 04:

  Malleter, M., et al. Int. J. Mol. Med. 25 (6) :897-903 (2010)

• Other Product Names:

  Enhancer of filamentation 1, hEF1, CRK-associated substrate-related protein, CAS-L, CasL, Cas scaffolding protein family member 2, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, Renal carcinoma antigen NY-REN-12, p105, Enhancer of filamentation 1 p55, NEDD9, CASL, CASS2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  8134360

• Physical Properties:

  Liquid