E Cadherin Antibody

• Background:

  CDH1 is a classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.

• NCBI Gene ID:

  999

• Swiss Prot:

  P12830

• Accession Number:

  P12830

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This E Cadherin (CDH1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the N-terminal region of human E Cadherin (CDH1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  97 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDH1

• NCBI Official Name:

  Cadherin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mansouri, A., Differentiation 38 (1), 67-71 (1988) Knudsen, K.A. J. Cell Biol. 118 (3), 671-679 (1992) Hsu, Y.M., Cancer Res. 67 (22), 11064-11073 (2007)

• Other Product Names:

  Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO

• Tested Applications:

  WB, Flow

• Protein ID:

  399166

• Physical Properties:

  Liquid