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E Cadherin Recombinant Protein

CAT: 0223-96-253Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-253Size:0.1 mg
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Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC) .
CAS Number
9000-83-3
NCBI Gene ID
999
Swiss Prot
P12830
Accession Number
AAI41839
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Signal Transduction, Stem Cell, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
92.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Cadherin 1, type 1, E-cadherin (epithelial)
NCBI Organism
Homo sapiens
Background Reference 01
Agiostratidou G., et al., 2006, J. Neurochem. 96:1182-1188.
Background Reference 02
Meng Y.G., et al., 2007, Cell Res. 17:869-880.
Background Reference 03
Yoon K.-A., et al., 1999, J. Hum. Genet. 44:177-180.
Other Product Names
Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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