VE Cadherin Antibody

• Background:

  CDH5 is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.

• NCBI Gene ID:

  1003

• Swiss Prot:

  P33151

• Accession Number:

  P33151

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This VE Cadherin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the N-terminal region of human VE Cadherin.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDH5

• NCBI Official Name:

  Cadherin-5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Breviario F., Arterioscler. Thromb. Vasc. Biol. 15:1229-1239 (1995)

• Background Reference 02:

  Ali J., Microcirculation 4:267-277 (1997)

• Background Reference 03:

  Suzuki S., Cell Regul. 2:261-270 (1991)

• Other Product Names:

  Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5

• Tested Applications:

  WB, Flow

• Protein ID:

  322510142

• Physical Properties:

  Liquid