K Cadherin Antibody

• Background:

  CDH6 is a type II classical cadherin from the cadherin superfamily. It is a calcium dependent cell-cell adhesion membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of the CDH6 gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

• NCBI Gene ID:

  1004

• Swiss Prot:

  P55285

• Accession Number:

  P55285

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This K Cadherin (CDH6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the N-terminal region of human K Cadherin (CDH6) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDH6

• NCBI Official Name:

  Cadherin-6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, T., J. Proteome Res. (6), 2070-2080 (2005) Shimoyama, Y., Biochem. J. 349 (PT 1), 159-167 (2000) Shimoyama, Y., J. Biol. Chem. 274 (17), 11987-11994 (1999)

• Other Product Names:

  Cadherin-6, Kidney cadherin, K-cadherin, CDH6

• Tested Applications:

  WB

• Protein ID:

  1705545

• Physical Properties:

  Liquid