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E Cadherin (CD324) Antibody

CAT: 0223-79-670Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-670Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
NCBI Gene ID
999
Swiss Prot
P12830
Accession Number
NP_004351.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E-Cadherin (CD324) antibody was raised against a peptide sequence around aa.864~868 (E-W-G-N-R) derived from Human E-Cadherin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
135 kDa
Specificity
This antibody detects endogenous level of total E-Cadherin protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
CDH1
NCBI Official Name
Cadherin 1, type 1, E-cadherin (epithelial)
NCBI Organism
Homo sapiens
Background Reference 01
Baki L. et. al (2001) Proc. Natl. Acad. Sci. U. S. A. 98:2381-2386Makagiansar I. T. et. al (2002) J. Biol. Chem. 277:16002-16010Agiostratidou G. (2006) J. Neurochem. 96:1182-1188
Other Product Names
UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1, UVO
Tested Applications
WB
Protein ID
4757960
Physical Properties
Liquid

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