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MCM6 Antibody

CAT: 0223-57-953Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-953Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
NCBI Gene ID
4175
Swiss Prot
Q14566
Accession Number
Q14566
Host
Rabbit
Reactivity
Human
Immunogen
This MCM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the N-terminal region of human MCM6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
93 kDa
Fragment
Rabbit Ig
Symbol
MCM6
NCBI Official Name
DNA replication licensing factor MCM6
NCBI Organism
Homo sapiens
Background Reference 01
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 02
Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1341-1348 (2010)
Background Reference 03
Wei, Z., et al. J. Biol. Chem. 285 (17) :12469-12473 (2010)
Background Reference 04
Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :
Other Product Names
DNA replication licensing factor MCM6, p105MCM, MCM6
Tested Applications
WB, IHC-P
Protein ID
2497824
Physical Properties
Liquid

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