MCM6 Antibody

• Background :

  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

• NCBI Gene ID :

  4175

• Swiss Prot :

  Q14566

• Accession Number :

  Q14566

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MCM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the N-terminal region of human MCM6.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  93 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MCM6

• NCBI Official Name :

  DNA replication licensing factor MCM6

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 02 :

  Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1341-1348 (2010)

• Background Reference 03 :

  Wei, Z., et al. J. Biol. Chem. 285 (17) :12469-12473 (2010)

• Background Reference 04 :

  Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :

• Other Product Names :

  DNA replication licensing factor MCM6, p105MCM, MCM6

• Tested Applications :

  WB, IHC-P

• Protein ID :

  2497824

• Physical Properties :

  Liquid