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MCM7 Antibody

CAT: 0223-58-402Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-402Size:400 µL
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
NCBI Gene ID
4176
Swiss Prot
P33993
Accession Number
P33993
Host
Rabbit
Reactivity
Human
Immunogen
This MCM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the N-terminal region of human MCM7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
81 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MCM7
NCBI Official Name
DNA replication licensing factor MCM7
NCBI Organism
Homo sapiens
Background Reference 01
Lau, K.M., et al. Oncogene 29 (40) :5475-5489 (2010)
Background Reference 02
Kim, D.W., et al. Mol. Biochem. Parasitol. 173 (1) :10-16 (2010)
Background Reference 03
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 04
Rojiani, M.V., et al. Appl. Immunohistochem. Mol. Morphol. 18 (3) :278-282 (2010)
Other Product Names
DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2
Tested Applications
WB
Protein ID
20981696
Physical Properties
Liquid

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