MCM2 Antibody

• Background:

  MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

• NCBI Gene ID:

  4171

• Swiss Prot:

  P49736

• Accession Number:

  P49736

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MCM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human MCM2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  102 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MCM2

• NCBI Official Name:

  DNA replication licensing factor MCM2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Saade, E., et al. Proteomics 9 (21) :4934-4943 (2009)

• Background Reference 02:

  Xu, X., et al. EMBO J. 28 (19) :3005-3014 (2009)

• Background Reference 03:

  Liaw, K., et al. J. Cutan. Pathol. 36 (10) :1121-1122 (2009)

• Background Reference 04:

  Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (37) :15628-15632 (2009)

• Other Product Names:

  DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030

• Tested Applications:

  WB, IHC-P

• Protein ID:

  41019490

• Physical Properties:

  Liquid