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MCM2 Antibody

CAT: 0223-63-916Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-916Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
NCBI Gene ID
4171
Swiss Prot
P49736
Accession Number
P49736
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MCM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human MCM2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
102 kDa
Fragment
Rabbit Ig
Symbol
MCM2
NCBI Official Name
DNA replication licensing factor MCM2
NCBI Organism
Homo sapiens
Background Reference 01
Saade, E., et al. Proteomics 9 (21) :4934-4943 (2009)
Background Reference 02
Xu, X., et al. EMBO J. 28 (19) :3005-3014 (2009)
Background Reference 03
Liaw, K., et al. J. Cutan. Pathol. 36 (10) :1121-1122 (2009)
Background Reference 04
Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (37) :15628-15632 (2009)
Other Product Names
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Tested Applications
WB, IHC-P
Protein ID
41019490
Physical Properties
Liquid

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