MCM7 Antibody

CAT: 0223-28-539Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-28-539Size:100 µL
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Background
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
NCBI Gene ID
4176
Swiss Prot
P33993
Accession Number
NP_005907
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MCM7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1224 - Daudi Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MCM7 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
81 kDa, 61 kDa
Applications Notes
MCM7 antibody can be used for detection of MCM7 by ELISA at 1:312500. MCM7 antibody can be used for detection of MCM7 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MCM7
NCBI Official Name
Minichromosome maintenance complex component 7
NCBI Organism
Homo sapiens
Background Reference 01
Ren, B., (2006) Oncogene 25 (7), 1090-1098.
Other Product Names
MCM7, MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
Tested Applications
ELISA, WB, IHC
Protein ID
33469968
Physical Properties
Liquid

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