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NR1I3 Antibody

CAT: 0223-57-837Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-837Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
9970
Swiss Prot
Q14994
Accession Number
Q14994
Host
Rabbit
Reactivity
Human
Immunogen
This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NR1I3
NCBI Official Name
Nuclear receptor subfamily 1 group I member 3
NCBI Organism
Homo sapiens
Background Reference 01
Benet, M., et al. J. Biol. Chem. 285 (37) :28457-28471 (2010)
Background Reference 02
Oliver, P., et al. Clin. Chem. Lab. Med. 48 (5) :635-639 (2010)
Background Reference 03
Masuyama, H., et al. Mol. Endocrinol. 24 (4) :745-753 (2010)
Background Reference 04
Mutoh, S., et al. J. Biol. Chem. 284 (50) :34785-34792 (2009)
Other Product Names
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Tested Applications
WB
Protein ID
49066046
Physical Properties
Liquid

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