NR1H3 Antibody

• Background:

  Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.

• NCBI Gene ID:

  10062

• Swiss Prot:

  Q13133

• Accession Number:

  NP_005684

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1H3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer, Signal Transduction

• Purification:

  Antibody is purified by protein A chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR1H3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  50 kDa

• Applications Notes:

  NR1H3 antibody can be used for detection of NR1H3 by ELISA at 1:1562500. NR1H3 antibody can be used for detection of NR1H3 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  NR1H3

• NCBI Official Name:

  Nuclear receptor subfamily 1, group H, member 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Albers, M., et al., (2006) J. Biol. Chem. 281 (8), 4920-4930.

• Other Product Names:

  NR1H3, LXRA, LXR-a, RLD-1

• Tested Applications:

  ELISA, WB

• Protein ID:

  194294517

• Physical Properties:

  Liquid