EIF2AK3 Antibody

CAT: 0223-57-811Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-811Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
NCBI Gene ID
9451
Swiss Prot
Q9NZJ5
Accession Number
Q9NZJ5
Host
Rabbit
Reactivity
Human
Immunogen
This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human EIF2AK3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
125 kDa
Fragment
Rabbit Ig
Symbol
EIF2AK3
NCBI Official Name
Eukaryotic translation initiation factor 2-alpha kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Xu, H., et al. Toxicology 277 (1-3), 1-5 (2010) :
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 04
Kim, K.W., et al. Oncogene 29 (22) :3241-3251 (2010)
Other Product Names
Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK
Tested Applications
WB, IHC-P
Protein ID
296439367
Physical Properties
Liquid

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