EIF2AK3 Antibody

• Background:

  The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

• NCBI Gene ID:

  9451

• Swiss Prot:

  Q9NZJ5

• Accession Number:

  Q9NZJ5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human EIF2AK3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  125 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EIF2AK3

• NCBI Official Name:

  Eukaryotic translation initiation factor 2-alpha kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xu, H., et al. Toxicology 277 (1-3), 1-5 (2010) :

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Kim, K.W., et al. Oncogene 29 (22) :3241-3251 (2010)

• Other Product Names:

  Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK

• Tested Applications:

  WB, IHC-P

• Protein ID:

  296439367

• Physical Properties:

  Liquid