EIF2B3 Antibody

• Background :

  EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.

• NCBI Gene ID :

  8891

• Swiss Prot :

  Q9NR50

• Accession Number :

  Q9NR50

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-376 amino acids from the C-terminal region of human EIF2B3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  50 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  EIF2B3

• NCBI Official Name :

  Translation initiation factor eIF-2B subunit gamma

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Van der Knaap, M.S., et al., Ann. Neurol. 51 (2) :264-270 (2002) .

• Background Reference 02 :

  Kruger, M., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (15) :8566-8571 (2000) .

• Background Reference 03 :

  Gomez, E., et al., Mol. Cell. Biol. 20 (11) :3965-3976 (2000) .

• Other Product Names :

  Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3

• Tested Applications :

  WB

• Protein ID :

  18203317

• Physical Properties :

  Liquid