COL18A1 Antibody

• Background:

  COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.

• NCBI Gene ID:

  80781

• Swiss Prot:

  P39060

• Accession Number:

  P39060

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  178 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COL18A1

• NCBI Official Name:

  Collagen alpha-1 (XVIII) chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hamano, Y., et al. J. Am. Soc. Nephrol. 21 (9) :1445-1455 (2010)

• Background Reference 02:

  Roberts, K.E., et al. Gastroenterology 139 (1) :130-139 (2010)

• Background Reference 03:

  Lee, K.S., et al. Tumour Biol. 31 (3) :165-170 (2010)

• Background Reference 04:

  Faye, C., et al. Biochem. J. 427 (3) :467-475 (2010)

• Other Product Names:

  Collagen alpha-1 (XVIII) chain, Endostatin, COL18A1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215274264

• Physical Properties:

  Liquid