COL1A2 Antibody

• Background:

  This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].

• NCBI Gene ID:

  1278

• Swiss Prot:

  P08123

• Accession Number:

  P08123

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COL1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human COL1A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  129 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  COL1A2

• NCBI Official Name:

  Collagen alpha-2 (I) chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Blades, H.Z., et al. Bone 47 (5) :989-994 (2010)

• Background Reference 02:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Bozec, A., et al. J. Cell Biol. 190 (6) :1093-1106 (2010)

• Other Product Names:

  Collagen alpha-2 (I) chain, Alpha-2 type I collagen, COL1A2

• Tested Applications:

  WB

• Protein ID:

  296439507

• Physical Properties:

  Liquid