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COL2A1 Antibody

CAT: 0223-57-548Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-548Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alpha-1 chain of type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutant forms of this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
NCBI Gene ID
1280
Swiss Prot
P02458
Accession Number
P02458
Host
Rabbit
Reactivity
Human
Immunogen
This COL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1209-1237 amino acids from the C-terminal region of human COL2A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
142 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
COL2A1
NCBI Official Name
Collagen alpha-1 (II) chain
NCBI Organism
Homo sapiens
Background Reference 01
Olavarrieta, L., Clin. Genet. 73 (3), 262-267 (2008)
Background Reference 02
McAlinden, A., Hum. Mutat. 29 (1), 83-90 (2008)
Background Reference 03
Forzano, F., Am. J. Med. Genet.143 (23), 2815-2820 (2007)
Other Product Names
Collagen alpha-1 (II) chain, Alpha-1 type II collagen, Collagen alpha-1 (II) chain, Chondrocalcin, COL2A1
Tested Applications
WB
Protein ID
124056489
Physical Properties
Liquid

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