Mouse Map2k5 Antibody

• Background:

  Map2k5 acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.

• NCBI Gene ID:

  23938

• Swiss Prot:

  Q9WVS7

• Accession Number:

  Q9WVS7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Mouse Map2k5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of mouse Map2k5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Map2k5

• NCBI Official Name:

  Dual specificity mitogen-activated protein kinase kinase 5

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Spiering, D., et al. J. Biol. Chem. 284 (37) :24972-24980 (2009)

• Background Reference 02:

  Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :

• Background Reference 03:

  Sohn, S.J., et al. EMBO J. 27 (13) :1896-1906 (2008)

• Background Reference 04:

  Shishido, T., et al. Circ. Res. 102 (11) :1416-1425 (2008)

• Other Product Names:

  Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, Map2k5, Mek5, Mkk5, Prkmk5

• Tested Applications:

  WB

• Physical Properties:

  Liquid