HLA-G Antibody

• Background:

  HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

• NCBI Gene ID:

  3135

• Swiss Prot:

  P17693

• Accession Number:

  P17693

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HLA-G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of human HLA-G.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HLA-G

• NCBI Official Name:

  HLA class I histocompatibility antigen, alpha chain G

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Walpole, N.G., et.al., J. Mol. Biol. 397 (2), 467-480 (2010)

• Background Reference 02:

  Tian, W., et.sl., Tissue Antigens 75 (3), 227-234 (2010)

• Other Product Names:

  HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G, HLA-G, HLA-60, HLAG

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  122132

• Physical Properties:

  Liquid