HDAC7 Antibody

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  51564

• Swiss Prot:

  Q8WUI4

• Accession Number:

  Q8WUI4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HDAC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-875 amino acids from the C-terminal region of human HDAC7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  103 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HDAC7

• NCBI Official Name:

  Histone deacetylase 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Margariti, A., et al. Circ. Res. 106 (7) :1202-1211 (2010)

• Background Reference 03:

  Hutt, D.M., et al. Nat. Chem. Biol. 6 (1) :25-33 (2010)

• Background Reference 04:

  Malik, S., et al. Mol. Cell. Biol. 30 (2) :399-412 (2010)

• Other Product Names:

  Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a, HDAC7, HDAC7A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  30913097

• Physical Properties:

  Liquid