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HDAC3 Antibody

CAT: 0223-56-975Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-975Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq].
NCBI Gene ID
8841
Swiss Prot
O15379
Accession Number
O15379
Host
Rabbit
Reactivity
Human
Immunogen
This HDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of human HDAC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Symbol
HDAC3
NCBI Official Name
Histone deacetylase 3
NCBI Organism
Homo sapiens
Background Reference 01
Minamiya, Y., et al. Tumour Biol. 31 (5) :533-539 (2010)
Background Reference 02
Kim, H.C., et al. Cell. Mol. Life Sci. 67 (20) :3499-3510 (2010)
Background Reference 03
Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :
Background Reference 04
Kim, T., et al. Psychiatry Res 178 (2) :266-269 (2010)
Other Product Names
Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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