HDAC3 Antibody

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq].

• NCBI Gene ID:

  8841

• Swiss Prot:

  O15379

• Accession Number:

  O15379

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of human HDAC3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  49 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HDAC3

• NCBI Official Name:

  Histone deacetylase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Minamiya, Y., et al. Tumour Biol. 31 (5) :533-539 (2010)

• Background Reference 02:

  Kim, H.C., et al. Cell. Mol. Life Sci. 67 (20) :3499-3510 (2010)

• Background Reference 03:

  Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :

• Background Reference 04:

  Kim, T., et al. Psychiatry Res 178 (2) :266-269 (2010)

• Other Product Names:

  Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid