HDAC3 Antibody

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

• NCBI Gene ID:

  8841

• Swiss Prot:

  O15379

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 299-428 of human HDAC3 (NP_003874.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 47kDa

• Fragment:

  IgG

• Symbol:

  HDAC3

• Positive Control 2:

  U-937

• Positive Control 3:

  Jurkat

• Positive Control 4:

  293T

• Positive Control 5:

  HepG2

• NCBI Official Name:

  Histone deacetylase 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  HDAC3, RPD3, SMAP45, HD3, Histone deacetylase 3, RPD3-2

• Tested Applications:

  WB, IHC, IF, IP, ChIP

• Physical Properties:

  Liquid