Parp6 Antibody

• Background:

  Poly (ADP-ribosyl) ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly (ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly (ADP-ribosyl) ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

• NCBI Gene ID:

  56965

• Swiss Prot:

  Q2NL67

• Accession Number:

  Q2NL67

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-583 amino acids from the C-terminal region of human Parp6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PARP6

• NCBI Official Name:

  Poly [ADP-ribose] polymerase 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ame, J.C., Bioessays 26 (8), 882-893 (2004)

• Other Product Names:

  Poly [ADP-ribose] polymerase 6, PARP-6, ADP-ribosyltransferase diphtheria toxin-like 17, ARTD17, PARP6

• Tested Applications:

  WB

• Protein ID:

  116248567

• Physical Properties:

  Liquid