UNC5D Antibody

• Background:

  UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) .

• NCBI Gene ID:

  137970

• Swiss Prot:

  Q6UXZ4

• Accession Number:

  Q6UXZ4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UNC5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-511 amino acids from the Central region of human UNC5D.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  106 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  UNC5D

• NCBI Official Name:

  Netrin receptor UNC5D

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Wang, H., et al. Biochem. Biophys. Res. Commun. 370 (4) :594-598 (2008)

• Background Reference 03:

  Choy, K.W., et al. Physiol. Genomics 25 (1) :9-15 (2006)

• Background Reference 04:

  Zhong, Y., et al. Cereb. Cortex 14 (10) :1144-1152 (2004)

• Other Product Names:

  Netrin receptor UNC5D, Protein unc-5 homolog 4, Protein unc-5 homolog D, UNC5D, KIAA1777, UNC5H4

• Tested Applications:

  WB

• Protein ID:

  54036576

• Physical Properties:

  Liquid