DAZ4 Antibody

• Background:

  This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF) . Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

• NCBI Gene ID:

  57135

• Swiss Prot:

  Q86SG3

• Accession Number:

  Q86SG3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DAZ4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the Central region of human DAZ4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DAZ4

• NCBI Official Name:

  Deleted in azoospermia protein 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, B., et al. Hum. Reprod. 24 (6) :1507-1515 (2009)

• Background Reference 02:

  Lardone, M.C., et al. Fertil. Steril. 88 (5) :1318-1326 (2007)

• Background Reference 03:

  A, Z.C., et al. Yi Chuan 28 (9) :1057-1060 (2006)

• Background Reference 04:

  Kuo, P.L., et al. Fertil. Steril. 81 (4) :1034-1040 (2004)

• Other Product Names:

  Deleted in azoospermia protein 4, DAZ4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  44887840

• Physical Properties:

  Liquid