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DAZ4 Antibody

CAT: 0223-56-502Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-502Size:400 µL
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Background
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF) . Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
NCBI Gene ID
57135
Swiss Prot
Q86SG3
Accession Number
Q86SG3
Host
Rabbit
Reactivity
Human
Immunogen
This DAZ4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the Central region of human DAZ4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
DAZ4
NCBI Official Name
Deleted in azoospermia protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Kim, B., et al. Hum. Reprod. 24 (6) :1507-1515 (2009)
Background Reference 02
Lardone, M.C., et al. Fertil. Steril. 88 (5) :1318-1326 (2007)
Background Reference 03
A, Z.C., et al. Yi Chuan 28 (9) :1057-1060 (2006)
Background Reference 04
Kuo, P.L., et al. Fertil. Steril. 81 (4) :1034-1040 (2004)
Other Product Names
Deleted in azoospermia protein 4, DAZ4
Tested Applications
WB, IHC-P
Protein ID
44887840
Physical Properties
Liquid

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