DAZL Antibody

• Background:

  The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1618

• Swiss Prot:

  Q92904

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 186-295 of human DAZL (NP_001342.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  SH-SY5Y

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 36kDa

• Fragment:

  IgG

• Symbol:

  DAZL

• Positive Control 2:

  SGC-7901

• Positive Control 3:

  Rat testis

• NCBI Official Name:

  Deleted in azoospermia-like

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DAZL, deleted in azoospermia-like, HGNC:2685, DAZH, DAZL1, DAZLA, MGC26406, SPGYLA, deleted in azoospermia-like autosomal, germline specific RNA binding protein, spermatogenesis gene on the Y-like autosomal

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid