DAZ3 Antibody

• Background:

  This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF) . Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat.

• NCBI Gene ID:

  57054

• Swiss Prot:

  Q9NR90

• Accession Number:

  Q9NR90

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DAZ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human DAZ3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DAZ3

• NCBI Official Name:

  Deleted in azoospermia protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, B., et al. Hum. Reprod. 24 (6) :1507-1515 (2009)

• Background Reference 02:

  Lardone, M.C., et al. Fertil. Steril. 88 (5) :1318-1326 (2007)

• Background Reference 03:

  A, Z.C., et al. Yi Chuan 28 (9) :1057-1060 (2006)

• Background Reference 04:

  Kuo, P.L., et al. Fertil. Steril. 81 (4) :1034-1040 (2004)

• Other Product Names:

  Deleted in azoospermia protein 3, DAZ3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  44887842

• Physical Properties:

  Liquid