COL8A2 Antibody

• Background:

  This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2.

• NCBI Gene ID:

  1296

• Swiss Prot:

  P25067

• Accession Number:

  P25067

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COL8A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-599 amino acids from the C-terminal region of human COL8A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  67 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COL8A2

• NCBI Official Name:

  Collagen alpha-2 (VIII) chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hemadevi, B., et al. BMC Ophthalmol 10, (2010) :

• Background Reference 02:

  Afshari, N.A., et al. Invest. Ophthalmol. Vis. Sci. 50 (3) :1093-1097 (2009)

• Background Reference 03:

  Liskova, P., et al. BrOphthalmol 91 (12) :1717-1718 (2007)

• Background Reference 04:

  Aldave, A.J., et al. Cornea 26 (8) :963-965 (2007)

• Other Product Names:

  Collagen alpha-2 (VIII) chain, Endothelial collagen, COL8A2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  45644957

• Physical Properties:

  Liquid