TRAIL Antibody [HS501]

• Background:

  TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B) . Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC) . .

• NCBI Gene ID:

  8743

• Swiss Prot:

  P50591

• Accession Number:

  4507593

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human TRAIL.

• Clonality:

  Monoclonal

• Clone:

  HS501

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1

• Specificity:

  Recognizes human TRAIL.

• Applications Notes:

  Western Blot: (1:1000) .

• Symbol:

  TNFSF10

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Apo-2L; TNFSF10; CD253

• Tested Applications:

  WB

• Protein ID:

  NP_003801

• Physical Properties:

  Liquid