Trail Antibody

• Background:

  Trail Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. TRAIL (TNF-related apoptosis-inducing ligand) is a type II membrane protein and expressed in a variety of human tissues (1,2) . The death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-6) . Like TNF and Fas ligand, TRAIL induces apoptosis and NF-κ B activation in many tissues and cells.

• NCBI Gene ID:

  8743

• Swiss Prot:

  P50591

• Accession Number:

  NP_003801

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Trail Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/ml

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (82%)

• Buffer:

  Trail Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Trail antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TNFSF10

• Positive Control 2:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Positive Control 3:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3:673-82.

• Background Reference 02:

  Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996; 271:12687-90.

• Background Reference 03:

  Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science; 1997; 276:111-3.

• Background Reference 04:

  Schneider P, Thome M, Burns K, et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κ B. Immunity 1997; 7:831-6.

• Other Product Names:

  Trail Antibody: TL2, APO2L, CD253, TRAIL, Apo-2L, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  4507593

• Physical Properties:

  Liquid