TRAIL Antibody [SB91c]

• Background:

  Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.

• NCBI Gene ID:

  8743

• Swiss Prot:

  P50591

• Accession Number:

  P50591

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant TRAIL

• Clonality:

  Monoclonal

• Clone:

  [SB91c]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2b

• Specificity:

  TRAIL

• Applications Notes:

  TRAIL Antibody [SB91c] for use in ELISA assays.

• Symbol:

  TNFSF10

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CD253, Apo-2 ligand, Apo-2L, TNFSF10

• Tested Applications:

  WB, IHC-Fr, Flow, IP

• Physical Properties:

  Liquid