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TRAIL Antibody [SB91c]

CAT: 0223-99-764Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0223-99-764Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
NCBI Gene ID
8743
Swiss Prot
P50591
Accession Number
P50591
Host
Mouse
Reactivity
Human
Immunogen
Recombinant TRAIL
Clonality
Monoclonal
Clone
[SB91c]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2b
Specificity
TRAIL
Applications Notes
TRAIL Antibody [SB91c] for use in ELISA assays.
Symbol
TNFSF10
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 10
NCBI Organism
Homo sapiens
Other Product Names
CD253, Apo-2 ligand, Apo-2L, TNFSF10
Tested Applications
WB, IHC-Fr, Flow, IP
Physical Properties
Liquid

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