TRAIL Antibody

• Background:

  Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain".

• NCBI Gene ID:

  8743

• Swiss Prot:

  P50591

• Accession Number:

  P50591

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hTRAIL/Apo2L (humanTRAIL/Apo2L) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies, Antibody Pairs

• Field of Research:

  Cancer, Apoptosis

• Purification:

  Anti-hTRAIL/Apo2L specific antibody was purified by affinity chromatography employing immobilized hTRAIL/Apo2L matrix.

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  TRAIL/Apo2L antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  TNFSF10

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TL2, APO2L, CD253, TRAIL, Apo-2L, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand

• Tested Applications:

  ELISA, WB, Neutralization Assay

• Protein ID:

  1730015

• Physical Properties:

  Lyophilized