Immunoproteasome activator 1

• UNSPSC Description:

  Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I–bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes[1].

• Target Antigen:

  Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/immunoproteasome-activator-1.html

• Smiles:

  O=C(C)C1=CC(NC(C2=CC3=C(C(CCCN4CCC5)=C4C5=C3)OC2=N)=O)=CC=C1

• Molecular Weight:

  401.46

• References & Citations:

  [1]Rana PS, et al. Immunoproteasome activation expands the MHC class I immunopeptidome, unmasks neoantigens and enhances T-cell antimyeloma activity. Mol Cancer Ther. 2024 Aug 30.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  901728-48-1