Ku70 + Ku80 Antibody [KU729]

• Background:

  This antibody recognizes a dimer of two proteins of 70kDa (Ku70) and ~80kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

• NCBI Gene ID:

  2547

• Swiss Prot:

  Q6FG89

• Host:

  Mouse

• Reactivity:

  Human, Primate

• Immunogen:

  Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

• Clonality:

  Monoclonal

• Clone:

  KU729

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Protein G purified monoclonal antibody

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Specificity:

  Does not react with mouse, rat, chicken

• Symbol:

  XRCC6

• NCBI Official Name:

  X-ray repair complementing defective repair in Chinese hamster cells 6

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  X-ray repair cross-complementing protein 6, 364-, 4299-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, XRCC6, G22P1

• Tested Applications:

  ICC, Flow, IF

• Physical Properties:

  Liquid