HMGB2 Antibody

CAT: 0223-27-448Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-448Size:100 µL
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Background
This protein is a member of the non-histone chromosomal high mobility group family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in the DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination.This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
3148
Swiss Prot
P26583
Accession Number
NP_002120
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HMGB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cell Cycle
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10426 - Fetal Thymus Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HMGB2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
24 kDa
Applications Notes
HMGB2 antibody can be used for detection of HMGB2 by ELISA at 1:312500. HMGB2 antibody can be used for detection of HMGB2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
HMGB2
NCBI Official Name
High mobility group box 2
NCBI Organism
Homo sapiens
Background Reference 01
McCauley, M.J., (2007) J. Mol. Biol. 374 (4), 993-1004.
Other Product Names
HMGB2, HMG2
Tested Applications
ELISA, WB
Protein ID
11321591
Physical Properties
Liquid

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