HMGA2 Antibody

CAT: 0223-61-900Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-900Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCBI Gene ID
8091
Swiss Prot
P52926
Accession Number
P52926
Host
Rabbit
Reactivity
Human
Immunogen
This HMGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
12 kDa
Fragment
Rabbit Ig
Symbol
HMGA2
NCBI Official Name
High mobility group protein HMGI-C
NCBI Organism
Homo sapiens
Background Reference 01
Mu, G., et al. Hum. Pathol. 41 (4) :493-502 (2010)
Background Reference 02
Pillas, D., et al. PLoS Genet. (2), E1000856 (2010) :
Background Reference 03
Yang, T.L., et al. Ann. Hum. Genet. 74 (1) :11-16 (2010)
Background Reference 04
Wei, J.J., et al. Am. J. Surg. Pathol. 34 (1) :18-26 (2010)
Other Product Names
High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC
Tested Applications
WB, Flow
Protein ID
1708263
Physical Properties
Liquid

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