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HMGB1 Antibody

CAT: 0223-7715-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7715-01Size:0.02 mg
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Background
The high-mobility group box 1 (HMGB1) protein was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression (1,2) . However, HMGB1 has more recently emerged as an extracellularly released mediator of inflammation and repair responses in lipopolysaccharide (LPS) -induced endotoxemia and sepsis (3) . HMGB1 has also been suggested to induce secretion of pro-inflammatory cytokines and chemokines by inducing NF-kB signaling downstream of Toll-like receptor (TLR) 2 and TLR4 activation (4) .
NCBI Gene ID
3146
Swiss Prot
P09429
Accession Number
NP_002119
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
7715
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KO Validation (Figure 1) : Anti-HMGB1 antibodies (7715) specificity was further verified by HMGB1 specific knockout cell lysate. HMGB1 signal was detected in wild type cells, but not in the HMGB1 knockout cells. KO Validation7715)
Field of Research
Innate Immunity
Purification
HMGB1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%), Pig: (100%)
Buffer
HMGB1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HMGB1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
HMGB1 antibody is human, mouse and rat reactive.
Isoform
Human HMGB1 has only 1 isoform (215aa, 25kD) . Mouse HMGB1 has only 1 isoform (215aa, 25kD) . Rat HMGB1 has only 1 isoform (215aa, 25kD) . This antibody detects HMGB1 of human, mouse and rat.
Symbol
HMGB1
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
High mobility group box 1
NCBI Organism
Homo sapiens
Background Reference 01
Smerdon MJ and Isenberg I. Interactions between the subfractions of calf thymus H1 and nonhistone chromosomal proteins HMG1 and HMG2. Biochemistry 1976; 15:4242-7.
Background Reference 02
Stros. Biocim. Biophys. Acta. 2010; 1799:101-113.
Background Reference 03
Wang et al. Science 1999; 285:248-51.
Background Reference 04
Van Zoelenet al. Shock 2009; 31:280-4.
Background Reference 05
Wei etal. Cell 2021; 184:76-91.
Other Product Names
HMGB1 Antibody: HMG1, HMG3, SBP-1, HMG1, High mobility group protein B1, High mobility group protein 1, HMG-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4504425
Physical Properties
Liquid

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