MAPK8 Antibody

• Background:

  JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

• NCBI Gene ID:

  5599

• Swiss Prot:

  P45983

• Accession Number:

  P45983

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human MAPK8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAPK8

• NCBI Official Name:

  Mitogen-activated protein kinase 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Deng, Y., et al., Cell 115 (1) :61-70 (2003) .

• Background Reference 02:

  Luo, W., et al., J. Biol. Chem. 278 (39) :37451-37458 (2003) .

• Background Reference 03:

  Ghosh, J., Biochem. Biophys. Res. Commun. 307 (2) :342-349 (2003) .

• Background Reference 04:

  Utsugi, M., et al., J. Immunol. 171 (2) :628-635 (2003) .

• Other Product Names:

  Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  2507195

• Physical Properties:

  Liquid