CTSC Antibody

• Background:

  This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

• NCBI Gene ID:

  1075

• Swiss Prot:

  P53634

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  NCI-H460

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 70kDa

• Fragment:

  IgG

• Symbol:

  CTSC

• Positive Control 2:

  293T

• Positive Control 3:

  SW620

• Positive Control 4:

  HL-60

• Positive Control 5:

  HeLa

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  Cathepsin C

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CTSC, cathepsin C, CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I, OTTHUMP00000235623, OTTHUMP00000235624, OTTHUMP00000235625, OTTHUMP00000235627, cathepsin J, dipeptidyl peptidase 1, dipeptidyl peptidase I, dipeptidyl transferase, dipeptidyl-peptidase

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid