ACO1 Antibody

CAT: 0223-23-238Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-23-238Size:100 µL
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Background
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
NCBI Gene ID
48
Swiss Prot
P21399
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ACO1 (NP_002188.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
LO2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 120kDa
Fragment
IgG
Symbol
ACO1
Positive Control 2
HeLa
Positive Control 3
A-549
Positive Control 4
DU145
Positive Control 5
HT-1080
Positive Control 6
Mouse liver
NCBI Official Name
Aconitase 1, soluble
NCBI Organism
Homo sapiens
Other Product Names
ACO1, IRP1, ACONS, HEL60, IREB1, IREBP, IREBP1
Tested Applications
WB, IHC
Physical Properties
Liquid

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