SHC1 Antibody

• Background:

  This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  6464

• Swiss Prot:

  P29353

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human SHC1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 46kDa, 52kDa, 66kDa

• Fragment:

  IgG

• Symbol:

  SHC1

• Positive Control 2:

  U-251MG

• Positive Control 3:

  MCF7

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Mouse heart

• Positive Control 6:

  Mouse brain

• NCBI Official Name:

  SHC (Src homology 2 domain containing) transforming protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SHC1, FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid