ING3 Antibody

• Background:

  The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

• NCBI Gene ID:

  54556

• Swiss Prot:

  Q9NXR8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human ING3 (NP_938008.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 50kDa

• Fragment:

  IgG

• Symbol:

  ING3

• Positive Control 2:

  SW620

• Positive Control 3:

  HeLa

• Positive Control 4:

  Rat testis

• NCBI Official Name:

  Inhibitor of growth family, member 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ING3, Eaf4, FLJ20089, ING2, p47ING3, MEAF4

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid