ING4 Antibody

• Background:

  Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) .

• NCBI Gene ID:

  51147

• Swiss Prot:

  Q9UNL4

• Accession Number:

  Q9UNL4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ING4

• NCBI Official Name:

  Inhibitor of growth protein 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shiseki M., et al.Cancer Res. 63:2373-2378 (2003) .

• Background Reference 02:

  Unoki M., et al.J. Biol. Chem. 281:34677-34686 (2006) .

• Background Reference 03:

  Raho G., et al.Oncogene 26:5247-5257 (2007) .

• Background Reference 04:

  Mao Y.M., et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.

• Other Product Names:

  Inhibitor of growth protein 4, p29ING4, ING4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  57012981

• Physical Properties:

  Liquid