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ING4 Antibody

CAT: 0223-61-026Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-026Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) .
NCBI Gene ID
51147
Swiss Prot
Q9UNL4
Accession Number
Q9UNL4
Host
Rabbit
Reactivity
Human
Immunogen
This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
ING4
NCBI Official Name
Inhibitor of growth protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Shiseki M., et al.Cancer Res. 63:2373-2378 (2003) .
Background Reference 02
Unoki M., et al.J. Biol. Chem. 281:34677-34686 (2006) .
Background Reference 03
Raho G., et al.Oncogene 26:5247-5257 (2007) .
Background Reference 04
Mao Y.M., et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Other Product Names
Inhibitor of growth protein 4, p29ING4, ING4
Tested Applications
WB, IHC-P
Protein ID
57012981
Physical Properties
Liquid

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