COL1A2 Antibody

• Background:

  This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

• NCBI Gene ID:

  1278

• Swiss Prot:

  P08123

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 500-600 of human COL1A2 (NP_000080.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Growth Factors, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  Mouse skin

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 125kDa

• Fragment:

  IgG

• Symbol:

  COL1A2

• Positive Control 2:

  Mouse skeletal muscle

• Positive Control 3:

  Rat skin

• NCBI Official Name:

  Collagen, type I, alpha 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  COL1A2, OI4

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid