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TXNRD2 Antibody

CAT: 0223-19-698Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-19-698Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.
NCBI Gene ID
10587
Swiss Prot
Q9NNW7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human TXNRD2 (NP_006431.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 56kDa
Fragment
IgG
Symbol
TXNRD2
Positive Control 2
HepG2
Positive Control 3
Mouse spleen
NCBI Official Name
Thioredoxin reductase 2
NCBI Organism
Homo sapiens
Other Product Names
GCCD5, SELZ, TR, TR-BETA, TR3, TRXR2, thioredoxin reductase 2, mitochondrial, selenoprotein Z, thioredoxin reductase 3, thioredoxin reductase TR3, thioredoxin reductase beta
Tested Applications
WB, IHC
Physical Properties
Liquid

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