TXNRD1 Antibody

• Background:

  Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

• NCBI Gene ID:

  7296

• Swiss Prot:

  Q16881

• Accession Number:

  Q16881

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TXNRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 516-550 amino acids from human TXNRD1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  TXNRD1

• NCBI Official Name:

  Thioredoxin reductase 1, cytoplasmic

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gasdaska P.Y., et al.FEBS Lett. 373:5-9 (1995) .

• Background Reference 02:

  Koishi R., et al.J. Biol. Chem. 272:2570-2577 (1997) .

• Background Reference 03:

  Hofman E.R., et al.Mol. Cell. Biol. 18:6493-6504 (1998) .

• Background Reference 04:

  Rundloef A.-K., et al.Free Radic. Biol. Med. 36:641-656 (2004) .

• Other Product Names:

  Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF

• Tested Applications:

  WB

• Protein ID:

  172046253

• Physical Properties:

  Liquid