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TXNRD1 Antibody

CAT: 0223-61-354Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-354Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
NCBI Gene ID
7296
Swiss Prot
Q16881
Accession Number
Q16881
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TXNRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 516-550 amino acids from human TXNRD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
TXNRD1
NCBI Official Name
Thioredoxin reductase 1, cytoplasmic
NCBI Organism
Homo sapiens
Background Reference 01
Gasdaska P.Y., et al.FEBS Lett. 373:5-9 (1995) .
Background Reference 02
Koishi R., et al.J. Biol. Chem. 272:2570-2577 (1997) .
Background Reference 03
Hofman E.R., et al.Mol. Cell. Biol. 18:6493-6504 (1998) .
Background Reference 04
Rundloef A.-K., et al.Free Radic. Biol. Med. 36:641-656 (2004) .
Other Product Names
Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF
Tested Applications
WB
Protein ID
172046253
Physical Properties
Liquid

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