TXNRD1 Antibody

• Background:

  This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

• NCBI Gene ID:

  7296

• Swiss Prot:

  Q16881

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein of human TXNRD1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 65kDa

• Fragment:

  IgG

• Symbol:

  TXNRD1

• Positive Control 2:

  BxPC-3

• Positive Control 3:

  Mouse heart

• NCBI Official Name:

  Thioredoxin reductase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TXNRD1, thioredoxin reductase 1, TR1, TXNR, GRIM12, KDRF

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid