RAD50 Antibody

• Background:

  The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

• NCBI Gene ID:

  10111

• Swiss Prot:

  Q92878

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RAD50 (NP_005723.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  A-549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 170kDa

• Fragment:

  IgG

• Symbol:

  RAD50

• Positive Control 2:

  MCF7

• Positive Control 3:

  293T

• Positive Control 4:

  HepG2

• Positive Control 5:

  NIH/3T3

• Positive Control 6:

  Mouse testis

• NCBI Official Name:

  RAD50 homolog (S. cerevisiae)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DNA repair protein RAD50, hRAD50, NBSLD, RAD502, hRad50

• Tested Applications:

  WB, IF, IP

• Physical Properties:

  Liquid