PROZ Antibody

• Background:

  This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  8858

• Swiss Prot:

  P22891

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human PROZ (NP_003882.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 48kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  PROZ

• Positive Control 2:

  293T

• Positive Control 3:

  Mouse kidney

• Positive Control 4:

  Rat liver

• Positive Control 5:

  Rat kidney

• NCBI Official Name:

  Protein Z, vitamin K-dependent plasma glycoprotein

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PROZ, Vitamin K-dependent protein Z, Protein Z, PZ

• Tested Applications:

  WB

• Physical Properties:

  Liquid