PROC Antibody

• Background:

  This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

• NCBI Gene ID:

  5624

• Swiss Prot:

  P04070

• Accession Number:

  P04070

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PROC

• NCBI Official Name:

  Vitamin K-dependent protein C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tang, W., et al. Blood (2010) In press :

• Background Reference 02:

  Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44 (4) :613-619 (2010)

• Background Reference 03:

  Witt, I., et al. Blood Coagul. Fibrinolysis 5 (4) :651-653 (1994)

• Background Reference 04:

  Zhang, L., et al. Blood 80 (4) :942-952 (1992)

• Other Product Names:

  Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  131067

• Physical Properties:

  Liquid